diff --git a/numpyro/infer/mcmc.py b/numpyro/infer/mcmc.py
index a1f7cb5d0..57c52a2da 100644
--- a/numpyro/infer/mcmc.py
+++ b/numpyro/infer/mcmc.py
@@ -389,6 +389,7 @@ def __init__(
         # HMCState returned by hmc.init_kernel
         self._init_state_cache = {}
         self._cache = {}
+        self._partial_map_fn: partial | None = None
         self._collection_params = {}
         self._set_collection_params()
 
@@ -699,13 +700,29 @@ def run(self, rng_key, *args, extra_fields=(), init_params=None, **kwargs):
         collect_fields = tuple(collect_fields.keys())
         remove_sites = tuple(remove_sites.keys())
 
-        partial_map_fn = partial(
-            self._single_chain_mcmc,
-            args=args,
-            kwargs=kwargs,
-            collect_fields=collect_fields,
-            remove_sites=remove_sites,
-        )
+        # Reuse the same partial object across run() calls so that
+        # jax.pmap sees a stable function identity and reuses the cached
+        # compilation.
+        # Since JAX 0.8.0 (aa2f995b1db548df5f1da92b43514f5314e75e4e),
+        # pmap is implemented via jit(shard_map) and jit caches by function
+        # identity: a new partial each call triggers a fresh trace + XLA compilation
+        # whose artifacts are never freed, causing unbounded memory
+        # growth.
+        if self._partial_map_fn is None:
+            self._partial_map_fn = partial(
+                self._single_chain_mcmc,
+                args=args,
+                kwargs=kwargs,
+                collect_fields=collect_fields,
+                remove_sites=remove_sites,
+            )
+        else:
+            self._partial_map_fn.keywords["args"] = args
+            self._partial_map_fn.keywords["kwargs"] = kwargs
+            self._partial_map_fn.keywords["collect_fields"] = collect_fields
+            self._partial_map_fn.keywords["remove_sites"] = remove_sites
+
+        partial_map_fn = self._partial_map_fn
         map_args = (rng_key, init_state, init_params)
         if self.num_chains == 1:
             states_flat, last_state = partial_map_fn(map_args)
diff --git a/test/infer/test_mcmc.py b/test/infer/test_mcmc.py
index 39637e23d..d76753d93 100644
--- a/test/infer/test_mcmc.py
+++ b/test/infer/test_mcmc.py
@@ -863,6 +863,36 @@ def get_samples(rng_key, data):
             )
 
 
+def test_reuse_mcmc_run_stable_partial_identity():
+    """Regression test: repeated run() calls must reuse the same partial object.
+
+    When pmap is implemented via jit(shard_map) (JAX >= 0.8.0), jit caches
+    by function identity. Creating a new functools.partial each run() call
+    causes a fresh trace + XLA compilation whose artifacts are never freed,
+    leading to unbounded memory growth in long-running services.
+    """
+
+    def model():
+        numpyro.sample("x", dist.Normal(0, 1))
+
+    mcmc = MCMC(
+        NUTS(model),
+        num_warmup=5,
+        num_samples=5,
+        num_chains=1,
+        progress_bar=False,
+    )
+    mcmc.run(random.key(0))
+    first_partial = mcmc._partial_map_fn
+    assert first_partial is not None
+
+    mcmc.run(random.key(1))
+    assert mcmc._partial_map_fn is first_partial, (
+        "_partial_map_fn must be the same object across run() calls "
+        "to avoid pmap/jit recompilation leaks"
+    )
+
+
 @pytest.mark.parametrize("num_chains", [1, 2])
 @pytest.mark.parametrize("chain_method", ["parallel", "sequential", "vectorized"])
 @pytest.mark.parametrize("progress_bar", [True, False])