Feature request: gene-level liability score for knockdown/knockout #4550

Hi @opentargets team — thanks for building and maintaining Open Targets' safety and genetics tooling (gentropy included); it's been a genuinely useful reference for how to structure on-target liability data, and it's saved us a lot of design time.

Would you consider a small feature for target liability evaluation? The idea: not every gene is safe to inhibit or knock down. A lightweight workflow could take a gene name as input and return (1) a human safety score for knockout/knockdown, and (2) the supporting safety signals behind it — essentiality, genetic constraint, critical-organ expression, on-target effects seen in genetics or drug data. Where red flags show up, that's a signal the gene may only tolerate partial inhibition or need tissue-restricted delivery rather than full knockdown.

Would appreciate it if the team could consider adding this — thanks for thinking it over.